In early Buddhism, dependent origination (pratitya-samutpada) was primarily used to explain the law of causation, the chain of cause, effect, and conditioning:
Ignorance > Karma > Consciousness > Name-Form > Senses > Contact > Feeling > Craving > Grasping > Becoming > Old age and death > Rebirth
The fundamental state of being is ignorance, conditioned by the imprints or seeds of past actions, habits and relationships (karma), which gives rise to consciousness, which is joined to name-form (the psycho-physical entity, specifically the embryo in the womb), which activates the six-senses; the senses come into contact with objects of desire and as a result, feeling, craving and grasping arise; these factors cause and condition the becoming of life and all that is becoming (existing) is subject to old age and death, and with the theory of rebirth, everything is set to be repeated in a future life, a continuum of consciousness within an seemingly endless cycle of birth and death.
By the time the Mahayana tradition was established, the focus of the analysis was less on how things come to be and more about how nothing can exist by itself, that everything is interconnected and inter-related. This is one reason why I interpret pratitya-samutpada as interdependence. Dependent origination or dependent arising sounds too much like a form of creationism.For Nagarjuna, the architect of Madhyamaka philosophy (you can learn more about Madhyamaka here) interdependence was synonymous with emptiness (sunyata).The true nature of reality (paramarthasatya) can be termed as the “emptiness of own-being” (svabhava-sunyata) and “interdependency” (pratitya-samutpada). Nagarjuna and the Madhyamaka’s taught that neither an individual nor dharma have an own-being that exists by its own right.
The Sanskrit word parikalpita, meaning imaginary or the “imagined.” In Chinese Buddhist terms defines it as “Counting everything as real, the way of the unenlightened; The nature of the unenlightened, holding to the tenet that everything is calculable or reliable, i.e. is what it appears to be.” Paraikapita is one of the three natures (tri-svabhava) that imagines a duality between subject and object. This imagined reality is an illusion, a thought construction superimposed on the true reality. Like a veil, it conceals the truth of emptiness/interdependency and all we see in our ordinary experience is an apparent reality, in which things appear to exist by their own right and seem to possess a nature or being that is permanent, independent, unconditioned and designed.
In Madhyamaka philosophy, any duality between subject and object is considered to be imagined (parikalpita again); there is no independently existing ‘experiencer’ apart from the experience, and experience can be also designated as a process.In the world of subatomic physics there are no objects, only processes. Atoms consist of particles but these particles are literally empty. So, we are aware now that reality is not particle-like but more like the nature of space. The common idea of space is an empty three-dimensional area. But there is no empty space (if by empty space, one means nothingness), space is actually permeated with an impalpable continuum. But the three dimensional aspect we perceive is somewhat of an illusion, or perhaps it would be more accurate to say it is not the full reality.
Finally, interdependency or pratitya-samutpada – the insubstantiality, the interconnectedness, the expansiveness of reality – is not only the foundation for all the diverse concepts in Buddhism, it is also the ground of the diverse world. Emptiness is the cause of interdependency and emptiness is not only a synonym for interdependence, it is also a synonym for something else
“That which is of the nature of coming and going, arising and perishing, in its saha (mundane) nature is itself Nirvana in its unconditioned (ultimate) nature.”
-Nagarjuna, “Treatise on the Maha Prajna-Paramita Sutra”